Our results suggest the role of estrogen metabolism in a direct regulation of TRPA1 activity with potential implications for metabolic diseases. Calcium influx and insulin secretion stimulated by estrogen metabolites were dependent on the TRPA1 activity and inhibited with the channel-specific pharmacological antagonists or the siRNA.
Exces de estrogen free#
Catechol estrogens also generated sustained elevations in cytosolic free calcium and evoked inward ion current in HEK293 cells expressing the transient receptor potential A1 (TRPA1) cation channel. In insulin-secreting cells, catechol estrogens produced rapid activation of calcium influx and elevation in cytosolic free calcium. Excesul de androgeni (hiperandrogenism) » Seciunea: Boli i androgeni sau hiperandrogenismul este cea mai frecventa tulburare endocrina la femeile de varsta reproductiva. 2-Hydroxyestrone, the most abundant endogenous estrogen metabolite, was more efficacious in stimulating insulin secretion than any other tested catechol estrogens. We show that catechol estrogens, hydroxylated at positions C2 and C4 of the steroid A ring, rapidly potentiated glucose-induced insulin secretion via a nongenomic mechanism. In this study, we evaluated the effects of major natural estrogen metabolites, catechol estrogens, on insulin secretion in pancreatic β-cells. Este cunoscut faptul c în perioada premergtoare menstruaiei, nivelul de estrogen din organismul unor femei poate scdea foarte mult, fapt ce cauzeaz transpiraie excesiv.Dei aceast situaie este specific perioadei premenstruale, este bine de tiut faptul c o scdere dramatic a nivelului. Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. Ce factori duc la transpiraie în exces indiferent de vreme: Menstruaia. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen metabolites in modulating pancreatic β-cell function. Stork S, Bots ML, Grobbee DE, van der Schouw YT.
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Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Multe dintre femei au probleme cu excesul de estrogen sau progesteron, fiind astfel mai expuse riscului de suferi de diverse afectiuni mai mult sau mai putin severe.